What is the difference between semaglutide and tirzepatide?
| Attribute | Semaglutide | Tirzepatide |
|---|---|---|
| Primary receptor activity | GLP-1 receptor agonist | GIP + GLP-1 receptor agonist |
| FDA-approved weight-management example | Wegovy | Zepbound |
| LevelsRx compounded starting price | $150/month | $240/month |
| LevelsRx form highlighted | Injection; oral compounded semaglutide also listed | Injection |
| Compounded version FDA-approved? | No | No |
| Prescription decision | Licensed clinician | Licensed clinician |
How does mechanism change the comparison?
Semaglutide targets GLP-1 signaling; tirzepatide targets both GIP and GLP-1 signaling. Mechanism is one attribute. It does not by itself determine the best medication for an individual patient.
Which option starts at a lower price on LevelsRx?
LevelsRx currently advertises compounded semaglutide from $150 per month and compounded tirzepatide from $240 per month. The $90 difference is only a starting-price comparison. It does not account for changes in dose, formulation, insurance, program terms or clinical suitability.
How do FDA-approved and compounded products differ?
Wegovy and Zepbound are FDA-approved products with approved labeling and manufacturing requirements. Compounded semaglutide and compounded tirzepatide are not FDA-approved. FDA has warned about dosing errors, fraudulent products and adverse events involving compounded GLP-1-related drugs.
What should influence the clinician's choice?
- Medical history and weight-related conditions.
- Medication contraindications and potential drug interactions.
- Prior response or intolerance.
- Route and formulation preferences.
- Insurance coverage and out-of-pocket cost.
- Availability of an appropriate, legitimate product.
- Ability to follow dosing and monitoring instructions.
Comparison FAQs
Which is better, semaglutide or tirzepatide?
There is no single answer for every patient. Tirzepatide and semaglutide differ in receptor activity, approved products, trial results, side-effect considerations, insurance coverage and individual medical fit.
Which one is cheaper on LevelsRx?
Based on LevelsRx starting prices viewed August 16, 2026, compounded semaglutide starts lower at $150/month compared with compounded tirzepatide at $240/month.
Can I switch between them without a clinician?
No. Medication changes should be handled by a licensed prescriber who can account for dose, timing, side effects, contraindications and the specific products involved.